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Aussie wound glue to save lives on battlefield

Sue Dunlevy, October 22, 2018 7:00PM News Corp Australia Network

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MeTro is a highly elastic and adhesive surgical glue that quickly seals wounds without the need for common staples or sutures and could transform how surgeries are performed. media_cameraMeTro is a highly elastic and adhesive surgical glue that quickly seals wounds without the need for common staples or sutures and could transform how surgeries are performed.

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An Australian scientist’s “wound glue” invention could save lives, improve surgery and help reduce scarring. The invention is ready to be tested on humans.

The glue, which works with a special UV* light, could seal terrible injuries, stop bleeding in just 60 seconds and help wounds heal in half the normal time.

The gel-like material has already been tested on animals and successfully sealed cuts in the arteries* and lungs of rodents and the lungs of pigs, without the need for stitches and staples.

The Returned and Services League, which is a support organisation for armed services men and women, is helping pay for the research.

The Sydney University scientist Professor Anthony Weiss, who invented the glue, now needs $1 million to cover the cost of human clinical testing.

The 'wound glue' invention to seal wounds could be very useful in surgery, so that internal wounds wouldn’t need stitches or staples. media_cameraThe ‘wound glue’ invention to seal wounds could be very useful in surgery, so that internal wounds wouldn’t need stitches or staples.

The product called MeTro is a type of recombinant tropoelastin. That means it is a substance that is made out of the building blocks of a protein called elastin, taken apart and put back together again. It is grown and harvested from bacteria and is an exact replica* of the protein that gives human body parts strength and elasticity — allowing blood vessels to expand and contract, the skin to stretch and muscles to move.

MeTro is an elastic and adhesive surgical glue that quickly seals wounds without the need for staples or stitches. media_cameraMeTro is an elastic and adhesive surgical glue that quickly seals wounds without the need for staples or stitches.

Professor Weiss said it will be able to immediately seal off blood flow in someone with traumatic injuries such as bomb victims.

“Imagine a severe injury, someone was injured by an IED (Improvised Explosive Device, or a type of bomb) and was on the ground suffering a major blood vessel bleed and their life was at stake,” he said.

“The key is to rapidly seal off the blood flow with a liquid sealant* (tropoelastin) squirted on the site. Then you would shine a special light on it to seal it,” he said.

“In less than one minute there would be an elastic seal flowing over the broken blood vessel and the person’s life would be saved,” Professor Weiss said.

When the substance comes in contact with tissue it solidifies into a gel that does not run off and it has special light-activated technology that helps it solidify and merge* with surrounding tissue when a particular type of light is shone on it.

The substance could help injured soldiers. Picture: iStock media_cameraThe substance could help injured soldiers. Picture: iStock

MeTro could also transform how surgery is done, allowing doctors to seal internal wounds in hard-to-reach areas without using stitches or staples.

It is ideal for sealing wounds in body tissues that continually expand and relax — such as lungs, hearts and arteries — that are otherwise at risk of reopening.

Professor Weiss says it could limit scar tissue and reduce the number of operations needed by people who suffer severe injuries.

Another version of the substance developed for use in cosmetic medicine as an injectable filler that can also treat stretch marks and scars was sold to a big pharmaceutical company called Allergan in February. Allergan is applying for government approval to use it in the US.

“One of the things that excites me is that you are doing things that helps people injured in the military but the benefits flow on to broader society,” Professor Weiss said.

“The ambulance could have it, it’s smart Aussie science,” he said.

The Tropoelastin project was instigated* by RSL National CEO Georgie Macris and the RSL National Special Projects team.

“The Returned & Services League of Australia is proud to be able to support the Weiss Laboratory, at the University of Sydney’s Charles Perkins Centre, in researching the potential life changing benefits of Tropoelastin,” said John Sheldrick the Chairman of RSL National Trustees.

“Many veterans of conflicts suffer from injuries obtained in service to our country and supporting such medical research is another way that the RSL continues with its objectives* in assisting veterans and their families,” he said.

Peter Hughes’ hand. Mr Hughes was badly burned in the Bali bombings but was healed using spray on skin. You can learn more about this invention below. Picture: Susan Brown media_cameraPeter Hughes’ hand. Mr Hughes was badly burned in the Bali bombings but was healed using spray on skin. You can learn more about this invention below. Picture: Susan Brown

ANOTHER LIFESAVING INVENTION

Surgeon Fiona Wood, who is British but based in Perth, Western Australia, is famous for her invention of spray-on skin for people who are burned.

The invention, which she developed with US scientist Marie Stoner, was a way of quickly making replacement cells to spray onto burns. The invention is continually improving.

At the moment, a small number of cells can be grown to a big quantity in five days, flown to where they are needed and be used on the injured person the next day. The skin cells either come from the person who is burned or from a skin donor.

Dr Wood led a team of medical experts to save 28 people who were burned by exploding bombs in Bali in 2002. In 2007 she travelled to Indonesia to help save people injured when an aeroplane crash landed.

She was Australian of the Year in 2005.

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GLOSSARY

UV: ultraviolet light, a type of light also found in sunshine

arteries: main tubes that carry blood from the heart around the body

replica: exact copy

sealant: thing that seals something

merge: move into and become part of

instigated: made it start

objectives: goals or aims

LISTEN TO THIS STORY

QUICK QUIZ

1. What does the “wound glue” need to make it work?

2. What has it been tested on so far?

3. If someone was injured in a bomb blast, what two steps would take place to stop bleeding with this invention?

4. Why would the RSL want this invention?

5. Describe Fiona Wood’s invention and how it is made.

CLASSROOM ACTIVITIES

Explain it two ways

Now that you know all about “wound glue”, do you think you could explain the concept to other people?

Write down two summaries of the invention, for two different audiences. Your choice of words and detail should be appropriate for the audience it is directed at.

The first summary should be how you would explain “wound glue” to a 4-year-old child.

The second summary should be how you would explain “wound glue” to an adult with a good understanding of science and medicine.

Extension: Professor Weiss needs $1 million to cover the cost of human clinical testing. Make a list of good reasons why a person or organisation should provide this funding.

Can you think of any reasons not to move on to human clinical testing?

Time: Allow 30 minutes

Curriculum links: English, Science

VCOP ACTIVITY

The glossary of terms helps you to understand and learn the ambitious vocabulary being used in the article. Can you use the words outlined in the glossary to create new sentences? Challenge yourself to include other VCOP (vocabulary, connectives, openers and punctuation) elements in your sentence/s. Have another look through the article, can you find any other Wow Words not outlined in the glossary?

HAVE YOUR SAY: If you had $1 million to spend only on medical research, would you sponsor the “wound glue” trials? Why or why not? Use full sentences to explain your thinking. No one-word answers.

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